Open AccessHMGA2, MicroRNAs, and Stem Cell Aging
Author(s) -
Scott M. Hammond,
Norman E. Sharpless
Publication year - 2008
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2008.11.026
Subject(s) - biology , stem cell , microrna , microbiology and biotechnology , somatic cell , chromatin , hmga2 , adult stem cell , genetics , cellular differentiation , gene
Mammalian aging results from a replicative decline in the function of somatic stem cells and other self-renewing cells. Recent studies (Monzen et al., 2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom