Open AccessDNA repair capacity correlates with standardized uptake values from 18 F‐fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small‐cell lung cancer
Author(s) -
Jiang Xin Eric,
Xu Ting,
Wei Qingyi,
Li Peng,
Gomez Daniel R.,
Court Laurence E.,
Liao Zhongxing
Publication year - 2018
Publication title -
chronic diseases and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2589-0514
DOI - 10.1016/j.cdtm.2018.05.003
Subject(s) - medicine , positron emission tomography , fluorodeoxyglucose , lung cancer , nuclear medicine , positron emission , radiology , oncology
Objective The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum‐based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non–small‐cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUV max ) on 18 F‐fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy. Methods This study included 151 patients with stage IA‐IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host‐cell reactivation assay with SUV max and their associations with overall survival (OS) time by hazards ratios calculated with a Cox proportional hazards regression model. Results SUV max of the primary tumor at diagnosis was inversely associated with lymphocyte DRC ( r = −0.175, P = 0.032), particularly among patients with advanced disease ( r = −0.218, P = 0.015). However, ΔSUV max of primary tumor was not significantly associated with DRC ( r = 0.005, P = 0.968). SUV max of regional lymph nodes at diagnosis ( r = −0.307, P = 0.0008) and after (chemo)radiation treatment ( r = −0.329, P = 0.034) and SUV max of the primary tumor after (chemo)radiation treatment ( r = −0.253, P = 0.045) were also inversely associated with OS time. Conclusion DRC was inversely associated with primary tumor SUV max before treatment but not with ΔSUV max after (chemo)radiation.