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Objective  The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum‐based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non–small‐cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUV max ) on 18 F‐fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy.    Methods  This study included 151 patients with stage IA‐IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host‐cell reactivation assay with SUV max  and their associations with overall survival (OS) time by hazards ratios calculated with a Cox proportional hazards regression model.    Results  SUV max  of the primary tumor at diagnosis was inversely associated with lymphocyte DRC ( r  = −0.175,  P  = 0.032), particularly among patients with advanced disease ( r  = −0.218,  P  = 0.015). However, ΔSUV max  of primary tumor was not significantly associated with DRC ( r  = 0.005,  P  = 0.968). SUV max  of regional lymph nodes at diagnosis ( r  = −0.307,  P  = 0.0008) and after (chemo)radiation treatment ( r  = −0.329,  P  = 0.034) and SUV max  of the primary tumor after (chemo)radiation treatment ( r  = −0.253,  P  = 0.045) were also inversely associated with OS time.    Conclusion  DRC was inversely associated with primary tumor SUV max  before treatment but not with ΔSUV max  after (chemo)radiation.

chronic diseases and translational medicine

DNA repair capacity correlates with standardized uptake values from  18 F‐fluorodeoxyglucose positron emission tomography/CT in patients with advanced non–small‐cell lung cancer