Open AccessKRAS ‐related noncoding RNAs in pancreatic ductal adenocarcinoma
Author(s) -
Yu ShuangNi,
Ma YiHui,
Zhao WuGan,
Jin XiangLan,
Yang HaiYan,
Liu PingPing,
Chen Jie
Publication year - 2016
Publication title -
chronic diseases and translational medicine
Language(s) - English
Resource type - Journals
ISSN - 2589-0514
DOI - 10.1016/j.cdtm.2016.11.012
Subject(s) - kras , pancreatic ductal adenocarcinoma , microrna , medicine , long non coding rna , disease , adenocarcinoma , cancer research , bioinformatics , oncology , pancreatic cancer , cancer , gene , biology , rna , colorectal cancer , genetics
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS ‐driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS ‐related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.