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Objective  Previous studies have revealed inconsistent results regarding the association between occult hepatitis B virus (HBV) infection and chronic kidney disease (CKD). Therefore, we conducted a prospective cohort study to evaluate the association between occult HBV infection and CKD.    Methods  A total of 4329 adults, aged 46.2 ± 13.7 years, without CKD at baseline were enrolled while undergoing physical examinations. Occult HBV infection was defined as seropositivity for antibody to HBV core antigen. CKD was defined as decreased estimated glomerular filtration rate (eGFR &lt; 60 ml·min −1 ·1.73 m −2 ) or presence of proteinuria ≥1+, assessed using a repeated dipstick method. eGFR was computed using the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equation.    Results  The prevalence of occult HBV infection was 8.1% (352/4329). During 5 years of follow‐up, 165 patients (3.8%) developed CKD. Univariate Logistic regression analysis showed that occult HBV infection was positively associated with decreased eGFR, with an odds ratio ( OR ) of 2.15 (95% confidence interval ( CI ): 1.05–4.11). In contrast, occult HBV infection was not associated with either proteinuria or CKD ( P  &gt; 0.05). After adjustment for potential confounders in the multivariate Logistic regression analysis, age, hypertension, diabetes, and the highest quartile of uric acid were associated with CKD, with  OR s of 1.04 (95%  CI : 1.02–1.05), 2.1 (95%  CI : 1.46–3.01), 2.02 (95%  CI : 1.36–2.99), and 1.86 (95%  CI : 1.17–2.95), respectively. However, occult HBV infection was not associated with CKD, with an  OR  of 1.12 (95%  CI : 0.65–1.95).    Conclusions  This study did not find an association between occult HBV infection and CKD. However, high‐risk patients infected with HBV should still be targeted for monitoring for the development of CKD.

Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population‐based cohort