Open AccessExpression of human ERG K channels in the mouse heart exerts anti-arrhythmic activity
Author(s) -
Anne Royer,
Sophie Demolombe,
Aziza El Harchi,
Khaï Le Quang,
Julien Piron,
Gilles Toumaniantz,
David Mazurais,
Chloé Bellocq,
Gilles Lande,
Cécile Terrenoire,
Howard Motoike,
Jean Chevallier,
Gildas Loussouarn,
Colleen E. Clancy,
Denis Escande,
Flavien Charpentier
Publication year - 2005
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1016/j.cardiores.2004.09.030
Subject(s) - herg , repolarization , transgene , genetically modified mouse , medicine , atrial action potential , qt interval , dofetilide , pharmacology , chemistry , endocrinology , electrophysiology , biology , potassium channel , biochemistry , gene
The K(+) channel encoded by the human ether-a-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of HERG current (I(Kr)) on the incidence of cardiac arrhythmias, we generated a transgenic mouse expressing HERG specifically in the heart.