Open AccessHIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries
Author(s) -
Brian S. Conklin,
Weiping Fu,
Peter H. Lin,
Alan B. Lumsden,
Qizhi Yao,
Changyi Chen
Publication year - 2004
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1016/j.cardiores.2004.03.020
Subject(s) - ritonavir , superoxide , endothelium , oxidative stress , endothelial dysfunction , pharmacology , endothelial stem cell , nitrotyrosine , lucigenin , chemistry , medicine , endocrinology , biology , nitric oxide , biochemistry , immunology , nitric oxide synthase , enzyme , in vitro , viral load , human immunodeficiency virus (hiv) , antiretroviral therapy
Although HIV Protease inhibitors significantly reduce the viral load, they are associated with increased risk of cardiovascular disease. The aim of this study was to investigate the effects of HIV protease inhibitor ritonavir on vascular endothelial cell function.