Open AccessA connectomic analysis of deep brain stimulation for treatment-resistant depression
Author(s) -
Zhoule Zhu,
Elizabeth Hubbard,
Xinxia Guo,
Daniel A. N. Barbosa,
Abdul Malik Popal,
Chengwei Cai,
Hongjie Jiang,
Zhe Zheng,
Jingquan Lin,
Wei Gao,
Jianmin Zhang,
Katrina Bartas,
Desiree Macchia,
Pieter Derdeyn,
Casey H. Halpern,
Helen S. Mayberg,
Kevin T. Beier,
Junming Zhu,
Hemmings Wu
Publication year - 2021
Publication title -
brain stimulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.685
H-Index - 81
eISSN - 1935-861X
pISSN - 1876-4754
DOI - 10.1016/j.brs.2021.08.010
Subject(s) - deep brain stimulation , neuroscience , treatment resistant depression , medial forebrain bundle , amygdala , tractography , white matter , human connectome project , diffusion mri , subthalamic nucleus , psychology , medicine , magnetic resonance imaging , major depressive disorder , striatum , functional connectivity , parkinson's disease , disease , dopamine , radiology
Deep brain stimulation (DBS) has been used as a treatment of last resort for treatment-resistant depression (TRD) for more than a decade. Many DBS targets have been proposed and tested clinically, but the underlying circuit mechanisms remain unclear. Uncovering white matter tracts (WMT) activated by DBS targets may provide crucial information about the circuit substrates mediating DBS efficacy in ameliorating TRD.
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