Coherence between the hippocampus and anterior thalamic nucleus as a tool to improve the effect of neurostimulation in temporal lobe epilepsy: An experimental study | Zendy

Ariana Sherdil | Zendy; Stéphan Chabardès | Zendy; Olivier David | Zendy; Brigitte Piallat | Zendy

Open Access

Coherence between the hippocampus and anterior thalamic nucleus as a tool to improve the effect of neurostimulation in temporal lobe epilepsy: An experimental study

Author(s) -

Ariana Sherdil,

Stéphan Chabardès,

Olivier David,

Brigitte Piallat

Publication year - 2020

Publication title -

brain stimulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.685

H-Index - 81

eISSN - 1935-861X

pISSN - 1876-4754

DOI - 10.1016/j.brs.2020.09.026

Subject(s) - ictal , deep brain stimulation , epilepsy , stimulation , neuroscience , temporal lobe , neurostimulation , thalamus , hippocampus , psychology , electroencephalography , medicine , parkinson's disease , disease

Although the mechanisms by which deep brain stimulation (DBS) modifies the activity of the ictal network are mostly undefined, recent studies have suggested that DBS of the anterior nucleus of the thalamus (ANT) can be an effective treatment for mesial temporal lobe epilepsy (MTLE) when resective surgery cannot be performed. In a nonhuman primate (NHP) model of MTL seizures, we showed that the ANT was actively involved during interictal and ictal periods through different patterns and that the hippocampus (HPC) and ANT synchronously oscillate in the high beta-band during seizures.

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