Repetitive Transcranial Magnetic Stimulation in adult patients with migraine: Report of 3 cases

and cognitive training were employed to assist in delaying early-onset AD manifestation. Methods: The patient completed pre-treatment questionnaires designed to test cognitive functioning; his spouse was interviewed to provide a third-party assessment. Following pre-treatment data collection, 65 daily rTMS/cognitive training sessions were completed over two cycles of 30 treatments, six months off, and 35 more treatments. The bilateral dorsolateral prefrontal cortices each received 1,000 pulses (10 Hz, 110% SMT). Tolerability data were collected after each treatment. Immediately following rTMS, the patient played cognitive training games. All pretreatment assessments were repeated at cycle completion for comparison of change in cognitive functionality. Results: Pre-treatment testing indicated the patient was asymptomatic. The patient completed 65 daily rTMS sessions. Tolerability/side effect data showed he tolerated treatment well and experienced only minor pain. The patient also completed 34 cognitive training sessions and showed moderate improvement across all cognitive domains. Post-treatment assessments indicated no change in functioning except to note the patient’s improved sleep. Conclusions: This case report supports rTMS paired with cognitive training to be a safe and tolerable treatment for early-onset AD. Randomized clinical trials must be completed before conclusions about its effectiveness can be determined. Conflicts of Interest: None to report Funding: This study was funded through the Center for Rehabilitation Sciences Research.