Open AccessOptogenetic translocation of protons out of penumbral neurons is protective in a rodent model of focal cerebral ischemia
Author(s) -
Bin Bo,
Yao Li,
Wanlu Li,
Yongting Wang,
Shanbao Tong
Publication year - 2020
Publication title -
brain stimulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.685
H-Index - 81
eISSN - 1935-861X
pISSN - 1876-4754
DOI - 10.1016/j.brs.2020.03.008
Subject(s) - optogenetics , ischemia , neuroscience , rodent , chromosomal translocation , rodent model , biology , medicine , biochemistry , ecology , gene
Intracellular acidosis in the ischemic penumbra can contribute to further cell death, effectively enlarging the infarct core. Restoring the acid-base balance may enhance tissue survivability after cerebral ischemia.
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