Investigating high- and low-frequency neuro-cardiac-guided TMS for probing the frontal vagal pathway | Zendy

Manreena Kaur | Zendy; Jessica Michael | Zendy; Kate E. Hoy | Zendy; Bernadette M. Fitzgibbon | Zendy; Megan S. Ross | Zendy; Tabitha A. Iseger | Zendy; Martijn Arns | Zendy; AbdulRahman Hudaib | Zendy; Paul B. Fitzgerald | Zendy

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Investigating high- and low-frequency neuro-cardiac-guided TMS for probing the frontal vagal pathway

Author(s) -

Manreena Kaur,

Jessica Michael,

Kate E. Hoy,

Bernadette M. Fitzgibbon,

Megan S. Ross,

Tabitha A. Iseger,

Martijn Arns,

AbdulRahman Hudaib,

Paul B. Fitzgerald

Publication year - 2020

Publication title -

brain stimulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.685

H-Index - 81

eISSN - 1935-861X

pISSN - 1876-4754

DOI - 10.1016/j.brs.2020.03.002

Subject(s) - transcranial magnetic stimulation , heart rate , psychology , neuroscience , heart rate variability , dorsolateral prefrontal cortex , cardiology , audiology , medicine , stimulation , prefrontal cortex , blood pressure , cognition

Investigating approaches for determining a functionally meaningful dorsolateral prefrontal cortex (DLPFC) stimulation site is imperative for optimising repetitive transcranial magnetic stimulation (rTMS) response rates for treatment-resistant depression. One proposed approach is neuro-cardiac-guided rTMS (NCG-TMS) in which high frequency rTMS is applied to the DLPFC to determine the site of greatest heart rate deceleration. This site is thought to index a frontal-vagal autonomic pathway that intersects a key pathway believed to underlie rTMS response.

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