A preliminary study of Parkinson’s gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice | Zendy

Chun-Yao Wu | Zendy; Rih-Yang Huang | Zendy; En-Chi Liao | Zendy; YuChun Lin | Zendy; Yi-Ju Ho | Zendy; ChienWen Chang | Zendy; HongLin Chan | Zendy; YingZu Huang | Zendy; Tsung-Hsun Hsieh | Zendy; ChingHsiang Fan | Zendy; ChihKuang Yeh | Zendy

Open Access

A preliminary study of Parkinson’s gene therapy via sono-magnetic sensing gene vector for conquering extra/intracellular barriers in mice

Author(s) -

Chun-Yao Wu,

Rih-Yang Huang,

En-Chi Liao,

YuChun Lin,

Yi-Ju Ho,

ChienWen Chang,

HongLin Chan,

YingZu Huang,

Tsung-Hsun Hsieh,

ChingHsiang Fan,

ChihKuang Yeh

Publication year - 2020

Publication title -

brain stimulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.685

H-Index - 81

eISSN - 1935-861X

pISSN - 1876-4754

DOI - 10.1016/j.brs.2020.02.024

Subject(s) - gene delivery , transfection , genetic enhancement , microbiology and biotechnology , intracellular , neurotrophic factors , chemistry , biology , gene , biochemistry , receptor

Non-virus genetic treatment for Parkinson's disease (PD) via plasmid glial cell-line derived neurotrophic factor (pGDNF) has shown potential for repairing damaged dopaminergic neurons. However, development of this gene therapy is largely hampered by the insufficient transfection efficiency as a result of the cell membrane, lysosome, and cytoskeleton meshwork.

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