Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC | Zendy

Ciara Borwick | Zendy; R. Lal | Zendy; Lee Wei Lim | Zendy; Charlotte J. Stagg | Zendy; Luca Aquili | Zendy

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Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC

Author(s) -

Ciara Borwick,

R. Lal,

Lee Wei Lim,

Charlotte J. Stagg,

Luca Aquili

Publication year - 2019

Publication title -

brain stimulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.685

H-Index - 81

eISSN - 1935-861X

pISSN - 1876-4754

DOI - 10.1016/j.brs.2019.08.016

Subject(s) - dopamine , flexibility (engineering) , neuroscience , transcranial direct current stimulation , psychology , cognitive flexibility , cognition , cognitive psychology , stimulation , statistics , mathematics

Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excitatory anodal tDCS of the dorsolateral prefrontal cortex (dlPFC) are causally related to cognitive flexibility as measured by task switching and reversal learning.

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