Effects of hydroalcoholic extract of Celtis iguanaea on markers of cardiovascular diseases and glucose metabolism in cholesterol-fed rats | Zendy

Barbara Zanchet | Zendy; Denise B. Gomes | Zendy; Vanessa da Silva Corralo | Zendy; Kriptsan Abdon Poletto Diel | Zendy; Amanda P. Schönell | Zendy; Caroline Faust | Zendy; Patrícia Avello Nicola | Zendy; Liz Girardi Müller | Zendy; Ana Paula Zanatta | Zendy; Silvana M. Wildner | Zendy; Fernanda Bevilaqua | Zendy; Rafael Chitolina | Zendy; Adrieli Sachett | Zendy; Leïla Zanatta | Zendy; Marta Maria Medeiros Frescura Duarte | Zendy; Greicy M. M. Conterato | Zendy; Cláudia Quintino da Rocha | Zendy; Camile Peretti | Zendy; Tatiane Brumelhaus | Zendy; Nayara Souza Alves | Zendy; Jean Carlo Olivo Menegatt | Zendy; Fernanda Conte | Zendy; Guilherme Serena | Zendy; Adriano Tony Ramos | Zendy; Francielli Cordeiro Zimermann | Zendy; Walter Antônio Roman | Zendy

Open Access

Effects of hydroalcoholic extract of Celtis iguanaea on markers of cardiovascular diseases and glucose metabolism in cholesterol-fed rats

Author(s) -

Barbara Zanchet,

Denise B. Gomes,

Vanessa da Silva Corralo,

Kriptsan Abdon Poletto Diel,

Amanda P. Schönell,

Caroline Faust,

Patrícia Avello Nicola,

Liz Girardi Müller,

Ana Paula Zanatta,

Silvana M. Wildner,

Fernanda Bevilaqua,

Rafael Chitolina,

Adrieli Sachett,

Leïla Zanatta,

Marta Maria Medeiros Frescura Duarte,

Greicy M. M. Conterato,

Cláudia Quintino da Rocha,

Camile Peretti,

Tatiane Brumelhaus,

Nayara Souza Alves,

Jean Carlo Olivo Menegatt,

Fernanda Conte,

Guilherme Serena,

Adriano Tony Ramos,

Francielli Cordeiro Zimermann,

Walter Antônio Roman

Publication year - 2017

Publication title -

revista brasileira de farmacognosia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 46

eISSN - 1981-528X

pISSN - 0102-695X

DOI - 10.1016/j.bjp.2017.12.001

Subject(s) - simvastatin , tbars , maltase , antioxidant , cholesterol , medicine , carbohydrate metabolism , endocrinology , diabetes mellitus , glycogen , lipid metabolism , hyperlipidemia , chemistry , lipid peroxidation , enzyme , biochemistry

Celtis iguanaea (Jacq.) Sarg., Cannabaceae, is popularly used in the treatment of diabetes mellitus. However, chemical and pharmacological investigations are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with C. iguanaea extract (C-150, CI-300, or CI-600 mg/kg) or simvastatin (4 mg/kg) (n = 6) once a day (30 days) with a hypercholesterolemic diet. A control group (C) was given saline. C. iguanaea extract showed significant decreases in serum levels of total cholesterol, LDL-cholesterol, HMG-CoA-reductase, interleukin-1 and 6, TNF-α and IFN-γ when compared to group C (p

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research