Open AccessEvaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study
Author(s) -
Cengiz Kaya,
Yunus Oktay Atalay,
Bilge Can Meydan,
Yasemin Burcu Üstün,
Ersin Köksal,
Sultan Çalışkan
Publication year - 2019
Publication title -
brazilian journal of anesthesiology (english edition)
Language(s) - English
Resource type - Journals
eISSN - 2352-2291
pISSN - 0104-0014
DOI - 10.1016/j.bjane.2019.04.004
Subject(s) - ketoprofen , medicine , spinal cord , anesthesia , chromatolysis , neurotoxicity , pharmacology , toxicity , psychiatry
Intrathecal (S)-(+)-Ketoprofen caused dose-dependent neurohistopathological changes in rats on days 3 and 7 after injection, suggesting that (S)-(+)-Ketoprofen should not be intrathecally administered.
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