Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene | Zendy

Aslam M. A. Mazari | Zendy; Bengt Mannervik | Zendy

Open Access

Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene

Author(s) -

Aslam M. A. Mazari,

Bengt Mannervik

Publication year - 2015

Publication title -

biochemistry and biophysics reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 23

ISSN - 2405-5808

DOI - 10.1016/j.bbrep.2015.12.003

Subject(s) - trinitrotoluene , biotransformation , detoxication , pollutant , drosophila melanogaster , bioremediation , environmental chemistry , xenobiotic , chemistry , glutathione transferase , glutathione , human health , contamination , biology , biochemistry , enzyme , explosive material , organic chemistry , ecology , gene , medicine , environmental health

The nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) and the related 2,4-dinitrotoluene (DNT) aretoxic environmental pollutants. The biotransformation and detoxication of these persistent compoundsin higher organisms are of great significance from a health perspective as well as for the biotechnological challenge of bioremediation of contaminated soil. We demonstrate that different human glutathionetransferases (GSTs) and GSTs from the fruit fly Drosophila melanogaster are catalysts of the biotransformationof TNT and DNT. The human GSTs had significant but modest catalytic activities with both DNT and TNT. However, D. melanogaster GSTE6 and GSTE7 displayed outstanding high activities withboth substrates

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