Editor Profile: Guest Editor of Special Issue on Targets and Anticancer Drug Research
Author(s) -
Liwu Fu
Publication year - 2017
Publication title -
acta pharmaceutica sinica b
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.912
H-Index - 51
eISSN - 2211-3843
pISSN - 2211-3835
DOI - 10.1016/j.apsb.2016.12.005
Subject(s) - anticancer drug , drug , pharmacology , computational biology , medicine , computer science , biology
China and became a professor since 2002. Dr. Fu has long standing research interests in cancer pharmacology and chemotherapy, especially the cancer multidrug resistance and TKIs' resistance as well as personalized chemotherapy. His original contribution includes establishing tumor living tissue susceptibility system in vitro, discovering drugs targeting ABC transporters to reversing MDR, and developing new anticancer agents. Large efforts in Dr. Fu laboratory have been devoted to studying multidrug resistance and its reversal as well as chemoresistance of cancer stem cell and therapy with an ultimate goal of developing novel reversal MDR therapeutics. His studies have revealed a number of TKIs, such as erlotinib, apatinib, vatalanib, afatinib, electinib, pelitinib, ibrutinib, and lapatinib, antagonize multidrug resistance– associated protein–mediated multidrug resistance by inhibiting its ABC transporters function. His research has also identified a novel compound PBA2, which showed excellent anti-tumor effect in various tumor cell lines. Dr. Fu has developed a novel robust platform to achieve a consistent, high-yield and large-scale production of natural and biologically-active reversal MDR agents. Dr. Fu has published over 240 peer-reviewed research and review papers, including 6 papers published in Cancer Research. The research in Dr. Fu's laboratory has been supported by several grants (National Natural Science Foundation of China/863 Project/973 Project). In addition to his research, Dr. Fu has been actively involved in teaching courses in cancer drug pharmacology and toxicology, and guiding graduate and doctorial students and post-doctors in research and career development. Dr. Fu vividly provides extensive services to the scientific community which includes various committees and advisory panels/boards. He is chairman of Board of He has also served as a reviewer for national research grants of Italy, Czech Republic, and China and has been invited to present his works in many international and national meetings.
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