Uncoupled Endothelial Nitric Oxide Synthase and Oxidative Stress in a Rat Model of Pregnancy-Induced Hypertension | Zendy

Bonnie Mitchell | Zendy; Leslie G. Cook | Zendy; Svitlana Danchuk | Zendy; Jules B. Puschett | Zendy

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Uncoupled Endothelial Nitric Oxide Synthase and Oxidative Stress in a Rat Model of Pregnancy-Induced Hypertension

Author(s) -

Bonnie Mitchell,

Leslie G. Cook,

Svitlana Danchuk,

Jules B. Puschett

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2007.08.007

Subject(s) - medicine , oxidative stress , nitric oxide synthase , nitric oxide , endothelial nitric oxide synthase , pregnancy , endothelial dysfunction , endocrinology , cardiology , enos , biology , genetics

Preeclampsia is a human pregnancy-associated syndrome associated with hypertension, proteinuria, and endothelial dysfunction. We tested whether increased reactive oxygen species (superoxide and peroxynitrite) production and decreased bioavailability of the endothelial nitric oxide (NO) synthase (eNOS) cofactor tetrahydrobiopterin (BH4) contributes to maternal endothelial dysfunction in rats with pregnancy-induced hypertension and several characteristics of preeclampsia.

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