Functional BSND Variants in Essential Hypertension* | Zendy

Saba Sile | Zendy; Niloufar B. Gillani | Zendy; Digna R. Velez | Zendy; Carlos G. Vanoye | Zendy; Chang Yu | Zendy; Loretta M. Byrne | Zendy; James V. Gainer | Zendy; Nancy J. Brown | Zendy; Scott M. Williams | Zendy; Alfred L. George | Zendy

Open Access

Functional <italic>BSND</italic> Variants in Essential Hypertension<xref ref-type="author-notes" rid="fn1"><sup>*</sup></xref><subtitle />

Author(s) -

Saba Sile,

Niloufar B. Gillani,

Digna R. Velez,

Carlos G. Vanoye,

Chang Yu,

Loretta M. Byrne,

James V. Gainer,

Nancy J. Brown,

Scott M. Williams,

Alfred L. George

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2007.07.003

Subject(s) - medicine , population , single nucleotide polymorphism , reabsorption , genetics , endocrinology , genotype , biology , gene , kidney , environmental health

Defects in the handling of renal salt reabsorption may contribute to interindividual differences in blood-pressure regulation and susceptibility to hypertension. Sodium chloride reabsorption in the thick ascending limb (TAL) is dependent in part on the chloride channel, ClC-Kb (encoded by CLCNKB), and its accessory subunit, barttin (encoded by BSND).

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