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Defects in the handling of renal salt reabsorption may contribute to interindividual differences in blood-pressure regulation and susceptibility to hypertension. Sodium chloride reabsorption in the thick ascending limb (TAL) is dependent in part on the chloride channel, ClC-Kb (encoded by CLCNKB), and its accessory subunit, barttin (encoded by BSND).

american journal of hypertension

Functional &lt;italic&gt;BSND&lt;/italic&gt; Variants in Essential Hypertension&lt;xref ref-type="author-notes" rid="fn1"&gt;&lt;sup&gt;*&lt;/sup&gt;&lt;/xref&gt;&lt;subtitle /&gt;