Circulating Succinate is Elevated in Rodent Models of Hypertension and Metabolic Disease | Zendy

Nalini Sadagopan | Zendy; Wenlin Li | Zendy; Steven L. Roberds | Zendy; Terry C. Major | Zendy; Gregory M. Preston | Zendy; Ying Yu | Zendy; Michael A. Tones | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Circulating Succinate is Elevated in Rodent Models of Hypertension and Metabolic Disease<subtitle />

Author(s) -

Nalini Sadagopan,

Wenlin Li,

Steven L. Roberds,

Terry C. Major,

Gregory M. Preston,

Ying Yu,

Michael A. Tones

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2007.05.010

Subject(s) - medicine , endocrinology , diabetes mellitus , blood pressure , receptor , type 2 diabetes , renin–angiotensin system

Recent evidence suggests that succinate, long known as an intermediate in the citric acid cycle, may also have a role as a signaling molecule through GPR91 and that activation of this receptor results in blood pressure (BP) elevation via the renin-angiotensin system. We sought to test the hypothesis that GPR91 contributes to BP elevation in hypertension. In addition we investigated whether elevated succinate in diabetes could contribute to the increased rate of gluconeogenesis in that condition.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research