Autocrine TGF-β1 Mediates Angiotensin II–Induced Proliferative Response of Cerebral Vessels In Vivo | Zendy

Vladimir V. Yurovsky | Zendy; Volodymyr Gerzanich | Zendy; Svetlana Ivanova | Zendy; Yuxiang Dong | Zendy; Orest Tsymbalyuk | Zendy; J. Marc Simard | Zendy

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Autocrine TGF-β1 Mediates Angiotensin II–Induced Proliferative Response of Cerebral Vessels In Vivo

Author(s) -

Vladimir V. Yurovsky,

Volodymyr Gerzanich,

Svetlana Ivanova,

Yuxiang Dong,

Orest Tsymbalyuk,

J. Marc Simard

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2007.03.013

Subject(s) - autocrine signalling , endocrinology , medicine , angiotensin ii , vascular smooth muscle , downregulation and upregulation , transforming growth factor , endothelium , in vivo , signal transduction , proliferating cell nuclear antigen , receptor , biology , microbiology and biotechnology , immunohistochemistry , biochemistry , smooth muscle , gene

Angiotensin II (Ang) has been shown to induce expression of transforming growth factor-beta1 (TGF-beta1) in cardiovascular cells in vitro, but the regulation of TGF-beta1 by Ang has not been shown in cerebral vessels in vivo. Here, we tested the hypothesis that Ang promotes proliferative and fibrogenic responses in cerebral vessels through autocrine production and signaling of TGF-beta1 by vascular smooth muscle cells (VSMC).

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