A Polymorphic GT Short Tandem Repeat Affecting β-ENaC mRNA Expression Is Associated With Low Renin Essential Hypertension | Zendy

Alexis A. González | Zendy; Cristián A. Carvajal | Zendy; Erick Riquelme | Zendy; Paola Krall | Zendy; Cristian Pérez Muñóz | Zendy; Lorena Mosso | Zendy; Alexis M. Kalergis | Zendy; Carlos Fardella | Zendy

Open Access

A Polymorphic GT Short Tandem Repeat Affecting β-ENaC mRNA Expression Is Associated With Low Renin Essential Hypertension

Author(s) -

Alexis A. González,

Cristián A. Carvajal,

Erick Riquelme,

Paola Krall,

Cristian Pérez Muñóz,

Lorena Mosso,

Alexis M. Kalergis,

Carlos Fardella

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2007.02.019

Subject(s) - essential hypertension , epithelial sodium channel , plasma renin activity , genotype , aldosterone , endocrinology , medicine , allele , renin–angiotensin system , polymerase chain reaction , microbiology and biotechnology , gene , sodium , genetics , biology , blood pressure , chemistry , organic chemistry

The epithelial sodium channel (ENaC) is a candidate gene associated with the development of essential hypertension. A potentially polymorphic repetitive region (GT dinucleotide short tandem repeat [STR]) was identified in intron 8 of beta-ENaC gene (SCNN1B). The aim of this study was to identify the prevalence and distribution of a polymorphic GT-STR in SCNN1B in Chilean essential hypertensive (EH) patients and to analyze the correlation between the different genotypes with plasma renin activity (PRA) and serum aldosterone (SA), and furthermore, to evaluate the beta-ENaC gene expression in vitro.

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