Therapeutic Actions of Allylmercaptocaptopril and Captopril in a Rat Model of Metabolic Syndrome | Zendy

Paul Ernsberger | Zendy; Jane M. F. Johnson | Zendy; Talma Rosenthal | Zendy; David Mirelman | Zendy; Richard J. Koletsky | Zendy

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Therapeutic Actions of Allylmercaptocaptopril and Captopril in a Rat Model of Metabolic Syndrome

Author(s) -

Paul Ernsberger,

Jane M. F. Johnson,

Talma Rosenthal,

David Mirelman,

Richard J. Koletsky

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2007.02.015

Subject(s) - captopril , medicine , endocrinology , blood pressure , angiotensin converting enzyme , creatinine , metabolic syndrome , diabetes mellitus

Hypertension often coexists with hyperlipidemia, insulin resistance, and glucose intolerance in metabolic syndrome. Allylmercaptocaptopril is a conjugate of the angiotensin-converting enzyme inhibitor captopril with allicin, an active principle in garlic with multiple beneficial actions on metabolic-syndrome abnormalities. We sought to test the hypothesis that the conjugation of allicin to captopril may confer additional therapeutic actions in metabolic disease.

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