Renin-Angiotensin Inhibition Reverses Advanced Cardiac Remodeling in Aging Spontaneously Hypertensive Rats | Zendy

Nobuyuki Ito | Zendy; Mitsuru Ohishi | Zendy; Kōichi Yamamoto | Zendy; Yuji Tatara | Zendy; Atsushi Shiota | Zendy; Norio Hayashi | Zendy; N KOMAI | Zendy; Yoshihiro Yanagitani | Zendy; Hiromi Rakugi | Zendy; Takehide Ogihara | Zendy

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Renin-Angiotensin Inhibition Reverses Advanced Cardiac Remodeling in Aging Spontaneously Hypertensive Rats

Author(s) -

Nobuyuki Ito,

Mitsuru Ohishi,

Kōichi Yamamoto,

Yuji Tatara,

Atsushi Shiota,

Norio Hayashi,

N KOMAI,

Yoshihiro Yanagitani,

Hiromi Rakugi,

Takehide Ogihara

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2007.02.004

Subject(s) - olmesartan , medicine , hydralazine , angiotensin ii , endocrinology , renin–angiotensin system , cardiac fibrosis , angiotensin ii receptor type 1 , angiotensin receptor , muscle hypertrophy , blood pressure , fibrosis

Many experiments using young hypertensive animal models support the evidence that angiotensin-converting enzyme inhibitor or angiotensin receptor type 1 blocker attenuates the progression of cardiac hypertrophy. However, it is still unclear whether inhibiting the renin-angiotensin system can reverse age-related cardiac hypertrophy. To clarify the role of renin-angiotensin system inhibition in naturally advanced myocardial hypertrophy we treated spontaneously hypertensive, aging rats with an angiotensin-converting enzyme inhibitor or an angiotensin receptor type 1 blocker.

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