High Sodium Intake Strengthens the Association of ACE I/D Polymorphism with Blood Pressure in a Community | Zendy

Kazumasa Yamagishi | Zendy; Tetsuya Tanigawa | Zendy; Ranji Cui | Zendy; Minako Tabata | Zendy; Akihiro Ikeda | Zendy; Min Yao | Zendy; T Shimamoto | Zendy; H. Iso | Zendy

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High Sodium Intake Strengthens the Association of ACE I/D Polymorphism with Blood Pressure in a Community

Author(s) -

Kazumasa Yamagishi,

Tetsuya Tanigawa,

Ranji Cui,

Minako Tabata,

Akihiro Ikeda,

Min Yao,

T Shimamoto,

H. Iso

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2007.01.018

Subject(s) - medicine , blood pressure , endocrinology , urine sodium , sodium , allele , angiotensin converting enzyme , polymorphism (computer science) , population , gene polymorphism , diastole , gene , genetics , biology , chemistry , environmental health , organic chemistry

Limited evidence is available on a gene-environment interaction of angiotensin-converting enzyme (ACE) gene I/D polymorphism and high blood pressure (BP) with salt intake among general populations. We hypothesized that persons with the I allele of the ACE gene have elevated BP levels in response to a higher sodium intake, and thus the association of ACE I/D polymorphism with BP levels was stronger among persons with a higher sodium intake than those with a lower sodium intake.

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