Open AccessKnockout Mice Reveal That the Angiotensin II type 1B Receptor Links to Smooth Muscle Contraction
Author(s) -
Albert N. Swafford,
Lisa M. HarrisonBernard,
Gregory M. Dick
Publication year - 2007
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1016/j.amjhyper.2006.09.007
Subject(s) - angiotensin ii , myograph , medicine , endocrinology , angiotensin receptor , receptor , contraction (grammar) , angiotensin ii receptor type 1 , knockout mouse
Rodents express two isoforms of the angiotensin II type 1 (AT(1)) receptor: AT(1A) and AT(1B). It is unclear which receptor subtype mediates contraction in response to angiotensin II in various arteries. We tested the hypothesis that the AT(1B) receptor is the predominant receptor that mediates contraction in the abdominal aorta in response to angiotensin II.