Effects of ACE Inhibition and β-Blockade on Plasminogen Activator Inhibitor-1 and Transforming Growth Factor-β1 in Carotid Glomus and Autonomic Ganglia in Hypertensive Rats | Zendy

Jorge E. Toblli | Zendy; Daniel Grana | Zendy; Guoliang Cao | Zendy; José Milei | Zendy

Open Access

Effects of ACE Inhibition and β-Blockade on Plasminogen Activator Inhibitor-1 and Transforming Growth Factor-β1 in Carotid Glomus and Autonomic Ganglia in Hypertensive Rats

Author(s) -

Jorge E. Toblli,

Daniel Grana,

Guoliang Cao,

José Milei

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.09.004

Subject(s) - medicine , endocrinology , plasminogen activator inhibitor 1 , spontaneously hypertensive rat , plasminogen activator , ramipril , ace inhibitor , tissue plasminogen activator , h&e stain , blood pressure , angiotensin converting enzyme , immunohistochemistry

Previous studies have demonstrated a high correlation between arterial hypertension and the development of lesions in the carotid glomus (CG) and autonomic ganglia (AG), characterized by extracellular matrix (ECM) expansion and reduction in the number of AG neurons. Because lowering blood pressure (BP) is the first step in controlling the deleterious effects of arterial hypertension, the objective was to evaluate possible differences between the beta-blocker atenolol (AT) and the angiotensin-converting enzyme (ACE) inhibitor ramipril (RAM) regarding a protective role on CG and AG, as target organs in the spontaneously hypertensive rat (SHR).

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