Antihypertensive and Renal Protective Effects of Renin-Angiotensin System Blockade in Uremic Rats Treated With Erythropoietin | Zendy

Michel Lebel | Zendy; Marie-Ève Rodrigue | Zendy; Mohsen Agharazii | Zendy; Roxanne Larivière | Zendy

Open Access

Antihypertensive and Renal Protective Effects of Renin-Angiotensin System Blockade in Uremic Rats Treated With Erythropoietin

Author(s) -

Michel Lebel,

Marie-Ève Rodrigue,

Mohsen Agharazii,

Roxanne Larivière

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.06.019

Subject(s) - medicine , captopril , losartan , endocrinology , erythropoietin , angiotensin ii , hydrochlorothiazide , blood pressure , glomerulosclerosis , kidney , proteinuria

Correcting anemia with recombinant human erythropoietin (rhEPO) in chronic renal failure has been associated with an increased blood pressure (BP), which may accelerate the decline in renal function. This has been attributed, in part, to the activation of the renin-angiotensin system. The present study was designed to investigate the protective effect of the angiotensin II-receptor blocker losartan compared with the angiotensin-converting enzyme inhibitor captopril and conventional triple therapy (TRx) in uremic rats receiving rhEPO therapy.

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