The G-231A Polymorphism in the Endothelin-A Receptor Gene Is Associated With Lower Aortic Pressure in Patients With Dilated Cardiomyopathy | Zendy

Ralph Telgmann | Zendy; Bassam A. Harb | Zendy; C. Özcelik | Zendy; Andreas Perrot | Zendy; Jacqueline Schönfelder | Zendy; A nenmacher | Zendy; Marcus Brand | Zendy; Klaus SchmidtPetersen | Zendy; Rainer Dietz | Zendy; Reinhold Kreutz | Zendy; K. J. Osterziel | Zendy; Martin Paul | Zendy; StefanMartin BrandHerrmann | Zendy

Open Access

The G-231A Polymorphism in the Endothelin-A Receptor Gene Is Associated With Lower Aortic Pressure in Patients With Dilated Cardiomyopathy

Author(s) -

Ralph Telgmann,

Bassam A. Harb,

C. Özcelik,

Andreas Perrot,

Jacqueline Schönfelder,

A nenmacher,

Marcus Brand,

Klaus SchmidtPetersen,

Rainer Dietz,

Reinhold Kreutz,

K. J. Osterziel,

Martin Paul,

StefanMartin BrandHerrmann

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.06.016

Subject(s) - medicine , allele , blood pressure , cardiology , dilated cardiomyopathy , polymorphism (computer science) , endothelin receptor , endocrinology , heart failure , receptor , genetics , gene , biology

The endothelin system (ES) plays an important role in blood pressure (BP) regulation and also in the pathophysiology of idiopathic dilated cardiomyopathy (DCM). Recently, we demonstrated that a genetic polymorphism in the endothelin A (ET(A)) receptor gene was associated with survival in DCM patients. The aim of this study was to determine whether polymorphisms in the ET(A) receptor gene might be associated with the severity of DCM.

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