Association Between the Calcitonin-Related Peptide α (CALCA) Gene and Essential Hypertension in Japanese Subjects | Zendy

A MORITA | Zendy; Toshinori Nakayama | Zendy; Masayoshi Soma | Zendy; Tetsuya Mizutani | Zendy

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Association Between the Calcitonin-Related Peptide α (CALCA) Gene and Essential Hypertension in Japanese Subjects

Author(s) -

A MORITA,

Toshinori Nakayama,

Masayoshi Soma,

Tetsuya Mizutani

Publication year - 2007

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.06.008

Subject(s) - medicine , calcitonin gene related peptide , calcitonin , essential hypertension , association (psychology) , gene , blood pressure , endocrinology , genetics , bioinformatics , neuropeptide , receptor , biology , philosophy , epistemology

Calcitonin-related peptide alpha (CALCA) is a neuropeptide that is a very potent vasodilator. It has been reported that CALCA knockout mice have a significantly elevated systolic blood pressure (BP). The aims of this study were to discover novel polymorphisms or mutations in the 5' flanking region of the human CALCA gene in Japanese subjects and to assess the association between this gene and essential hypertension (EH).

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