Aliskiren, an Orally Effective Renin Inhibitor, Provides Antihypertensive Efficacy Alone and in Combination With Valsartan | Zendy

James L. Pool | Zendy; R. Schmieder | Zendy; Michel Azizi | Zendy; JeanClaude Aldigier | Zendy; Andrzej Januszewicz | Zendy; Walter Zidek | Zendy; Y. Chiang | Zendy; Andrew Satlin | Zendy

Open Access

Aliskiren, an Orally Effective Renin Inhibitor, Provides Antihypertensive Efficacy Alone and in Combination With Valsartan

Author(s) -

James L. Pool,

R. Schmieder,

Michel Azizi,

JeanClaude Aldigier,

Andrzej Januszewicz,

Walter Zidek,

Y. Chiang,

Andrew Satlin

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.06.003

Subject(s) - aliskiren , valsartan , tolerability , medicine , placebo , pharmacology , hydrochlorothiazide , urology , blood pressure , combination therapy , renin–angiotensin system , adverse effect , alternative medicine , pathology

By blocking the renin-angiotensin-aldosterone system (RAAS) at its rate-limiting step, renin inhibition may provide improved RAAS suppression. We investigated the blood pressure (BP)-lowering effects of the oral direct renin inhibitor aliskiren, alone or in combination with the angiotensin receptor blocker valsartan.

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