Involvement of Ras-Regulated Myosin Light Chain Phosphorylation in the Captopril Effects in Spontaneously Hypertensive Rats | Zendy

Wen Hu | Zendy; Yongjae Han | Zendy; Lingkun Gu | Zendy; Mariann R. Piano | Zendy; Primal deLanerolle | Zendy

Open Access

Involvement of Ras-Regulated Myosin Light Chain Phosphorylation in the Captopril Effects in Spontaneously Hypertensive Rats

Author(s) -

Wen Hu,

Yongjae Han,

Lingkun Gu,

Mariann R. Piano,

Primal deLanerolle

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.05.024

Subject(s) - captopril , medicine , myosin light chain kinase , immunoglobulin light chain , phosphorylation , endocrinology , myosin , spontaneously hypertensive rat , pharmacology , blood pressure , microbiology and biotechnology , antibody , immunology , biology

Early treatment with captopril prevents the development of hypertension by inhibiting the generation of angiotensin II and smooth muscle contraction. Although smooth muscle contraction is regulated by myosin light chain phosphorylation (MLC-P), the role of MLC-P in captopril effects in hypertension has not been described. Therefore, we treated spontaneously hypertensive rats (SHR) with captopril and investigated the effects of this agent on downstream signaling.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research