Open AccessInability to Upregulate Cytochrome P450 4A and 2C Causes Salt Sensitivity in Young Sprague-Dawley Rats
Author(s) -
Sowndramalingam Sankaralingam,
Kaushik Desai,
Hartmut Glaeser,
R KIM,
Wilson Tw
Publication year - 2006
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1016/j.amjhyper.2006.04.007
Subject(s) - endocrinology , medicine , saline , excretion , clofibrate , blood pressure , cytochrome p450 , agonist , sodium , kidney , chemistry , receptor , metabolism , organic chemistry
Young Sprague-Dawley rats develop high blood pressure (BP) when exposed to a high salt intake, whereas adult ones generally do not. We investigated the role of renal cytochromes P450 4A (CYP 4A) and 2C (CYP 2C) in maintaining normal BP.
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