Chronic Effect of Combined Treatment With Omapatrilat and Adrenomedullin on the Progression of Heart Failure in Rats | Zendy

Toshio Nishikimi | Zendy; Yasukiyo Mori | Zendy; Ken Ishimura | Zendy; Yoshihiro Ishikawa | Zendy; Shozo Koshikawa | Zendy; K. Akimoto | Zendy; Naoto Minamino | Zendy; Kenji Kangawa | Zendy; H Matsuoka | Zendy

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Chronic Effect of Combined Treatment With Omapatrilat and Adrenomedullin on the Progression of Heart Failure in Rats

Author(s) -

Toshio Nishikimi,

Yasukiyo Mori,

Ken Ishimura,

Yoshihiro Ishikawa,

Shozo Koshikawa,

K. Akimoto,

Naoto Minamino,

Kenji Kangawa,

H Matsuoka

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.02.013

Subject(s) - adrenomedullin , medicine , endocrinology , plasminogen activator , heart failure , natriuretic peptide , ventricle , brain natriuretic peptide , atrial natriuretic peptide , hemodynamics , urotensin ii , receptor

We and other investigators have reported that short- and long-term treatment with adrenomedullin has beneficial effects in heart failure. This study examined the effects of long-term treatment with a vasopeptidase inhibitor plus adrenomedullin in a model of heart failure in rats and assessed potential mechanisms of action.

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