Ghrelin Inhibits Vascular Superoxide Production in Spontaneously Hypertensive Rats | Zendy

A Kawczyńska-Drózdz | Zendy; Rafał Olszanecki | Zendy; Jacek Jawień | Zendy; T BRZOZOWSKI | Zendy; W PAWLIK | Zendy; Ryszard Korbut | Zendy; Tomasz J. Guzik | Zendy

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Ghrelin Inhibits Vascular Superoxide Production in Spontaneously Hypertensive Rats

Author(s) -

A Kawczyńska-Drózdz,

Rafał Olszanecki,

Jacek Jawień,

T BRZOZOWSKI,

W PAWLIK,

Ryszard Korbut,

Tomasz J. Guzik

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.01.022

Subject(s) - superoxide , ghrelin , medicine , endocrinology , oxidative stress , appetite , pathogenesis , blood pressure , nadph oxidase , nad(p)h oxidase , nad+ kinase , receptor , enzyme , biochemistry , chemistry

Ghrelin is a novel peptide involved in the control of appetite, but its role in vascular pathologies remains to be elucidated. Ghrelin was shown to decrease blood pressure (BP) and improve endothelial function. Its plasma levels are correlated with BP in humans. Mechanisms of these effects are unknown. Because oxidative stress and increased superoxide production by NAD(P)H oxidases (Nox) are critical in the pathogenesis of hypertension, we aimed to study the effects of ghrelin on vascular superoxide production and NAD(P)H oxidase activity in spontaneously hypertensive rats (SHR).

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