Treatment of Combined Aortic Regurgitation and Systemic Hypertension: Insights From an Animal Model Study | Zendy

Jacques Couët | Zendy; Martin Gaudreau | Zendy; D. Lachance | Zendy; Éric Plante | Zendy; Élise Roussel | Zendy; Michel Drolet | Zendy; Marie Arsenault | Zendy

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Treatment of Combined Aortic Regurgitation and Systemic Hypertension: Insights From an Animal Model Study

Author(s) -

Jacques Couët,

Martin Gaudreau,

D. Lachance,

Éric Plante,

Élise Roussel,

Michel Drolet,

Marie Arsenault

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.01.021

Subject(s) - medicine , captopril , regurgitation (circulation) , cardiology , ventricle , ace inhibitor , aortic valve , animal model , angiotensin converting enzyme , blood pressure

Hypertension (HT) and aortic valve regurgitation (AR) often coexist but the specific impacts of AR + HT on the left ventricle (LV) are still unknown. The best treatment strategy for this combination of diseases is also unclear. The objectives of this study were 1) to evaluate LV function, remodeling and 2) to assess the effects of the angiotensin-converting enzyme (ACE) inhibitor captopril (C) in rats with AR +/- HT in spontaneously hypertensive rats (SHR).

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