Contractile Hyporesponsiveness to Norepinephrine of Forearm Veins in Chronic Renal Failure | Zendy

Gloria Segarra | Zendy; P LLUCH | Zendy; María Dolores Mauricio | Zendy; Jaime Vila | Zendy; Pascual Medina | Zendy; Juan Martínez-León | Zendy; Martı́n Aldasoro | Zendy; Salvador Lluch | Zendy

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Contractile Hyporesponsiveness to Norepinephrine of Forearm Veins in Chronic Renal Failure

Author(s) -

Gloria Segarra,

P LLUCH,

María Dolores Mauricio,

Jaime Vila,

Pascual Medina,

Juan Martínez-León,

Martı́n Aldasoro,

Salvador Lluch

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2006.01.007

Subject(s) - medicine , norepinephrine , forearm , hemodialysis , cardiology , nitric oxide , chronic renal failure , endocrinology , surgery , dopamine

We recently reported that endothelium-dependent relaxation is impaired in forearm veins from patients with chronic renal failure. However, assessment of responses to norepinephrine remains controversial. We examined the contractile response to norepinephrine in forearm veins from patients on chronic hemodialysis and the role of nitric oxide (NO), prostanoids, and Ca(2+)-activated K(+) channels in this response.

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