Modulation of Cardiac and Aortic Peroxisome Proliferator-Activated Receptor-γ Expression by Oxidative Stress in Chronically Glucose-Fed Rats | Zendy

Aouatef El-Midaoui | Zendy; Ling Wu | Zendy; Rui Wang | Zendy; J DECHAMPLAIN | Zendy

Open Access

Modulation of Cardiac and Aortic Peroxisome Proliferator-Activated Receptor-γ Expression by Oxidative Stress in Chronically Glucose-Fed Rats

Author(s) -

Aouatef El-Midaoui,

Ling Wu,

Rui Wang,

J DECHAMPLAIN

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.11.006

Subject(s) - pioglitazone , medicine , endocrinology , oxidative stress , insulin , insulin resistance , peroxisome proliferator activated receptor , receptor , diabetes mellitus , type 2 diabetes

The aim of the present study was to examine the chronic effects of alpha-lipoic acid on proliferator peroxisome activated receptors-gamma (PPAR-gamma) and PPAR-alpha expressions in cardiovascular tissues of chronically hypertensive insulinoresistant rats. We have also evaluated the chronic effects of high levels of insulin, glucose, or both on superoxide anion (O(2)(-)) production in aortic smooth muscle cells (SMCs) in the presence or in absence of pioglitazone, a PPAR-gamma agonist.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research