Tempol in the Dorsomedial Hypothalamus Attenuates the Hypertensive Response to Stress in Rabbits | Zendy

R DEMATTEO | Zendy; Geoffrey A. Head | Zendy; Dmitry N. Mayorov | Zendy

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Tempol in the Dorsomedial Hypothalamus Attenuates the Hypertensive Response to Stress in Rabbits

Author(s) -

R DEMATTEO,

Geoffrey A. Head,

Dmitry N. Mayorov

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.09.024

Subject(s) - microinjection , tiron , medicine , superoxide , endocrinology , medulla oblongata , heart rate , superoxide dismutase , blood pressure , oxidative stress , pharmacology , chemistry , biochemistry , central nervous system , enzyme

We have recently shown that microinjection of the superoxide dismutase mimetic tempol into the pressor region of the rostral ventrolateral medulla attenuates the cardiovascular response to mental (air-jet) stress in rabbits. In the present study, we examined the influence of tempol on the blood pressure (BP) and heart rate (HR) responses to stress in the key region of the hypothalamic defense area, the dorsomedial hypothalamus (DMH).

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