Apocynin but Not l-Arginine Prevents and Reverses Dexamethasone-Induced Hypertension in the Rat | Zendy

Lexian Hu | Zendy; Y ZHANG | Zendy; Pek Siew Lim | Zendy; Miao Ye | Zendy; Chrismin C. Tan | Zendy; K MCKENZIE | Zendy; C. G. Schyvens | Zendy; James Whitworth | Zendy

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Apocynin but Not l-Arginine Prevents and Reverses Dexamethasone-Induced Hypertension in the Rat

Author(s) -

Lexian Hu,

Y ZHANG,

Pek Siew Lim,

Miao Ye,

Chrismin C. Tan,

K MCKENZIE,

C. G. Schyvens,

James Whitworth

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.09.023

Subject(s) - apocynin , endocrinology , medicine , nitric oxide , nadph oxidase , nitric oxide synthase , oxidative stress , nad(p)h oxidase

Dexamethasone (Dex)-hypertension in rats is associated with increased oxidative stress. We investigated effects of the NAD(P)H oxidase inhibitor apocynin and the nitric oxide (NO) precursor L-arginine on Dex-hypertension to determine the relative roles of NAD(P)H oxidase and uncoupling in the reactive oxygen species (ROS) generation and hypertension.

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