Regulation of Angiogenic Factors in Angiotensin II Infusion Model in Association With Tubulointerstitial Injuries | Zendy

H Kitayama | Zendy; Yohei Maeshima | Zendy; Yuki Takazawa | Zendy; Yurie Yamamoto | Zendy; Yuzhang Wu | Zendy; Kunihiro Ichinose | Zendy; Kumiko Hirokoshi | Zendy; Hitoshi Sugiyama | Zendy; Yasuhiro Yamasaki | Zendy; Hirofumi Makino | Zendy

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Regulation of Angiogenic Factors in Angiotensin II Infusion Model in Association With Tubulointerstitial Injuries

Author(s) -

H Kitayama,

Yohei Maeshima,

Yuki Takazawa,

Yurie Yamamoto,

Yuzhang Wu,

Kunihiro Ichinose,

Kumiko Hirokoshi,

Hitoshi Sugiyama,

Yasuhiro Yamasaki,

Hirofumi Makino

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.09.022

Subject(s) - medicine , angiotensin ii , association (psychology) , pharmacology , blood pressure , philosophy , epistemology

Among various angiogenic factors, vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang1), and angiopoietin-2 (Ang2) play crucial roles in regulating angiogenesis and vascular integrity. Infusion of angiotensin-II (ang II) induces hypertension and focal renal tubulointerstitial injuries. In the present study we investigated the renal expression of VEGF, Ang1, Ang2, and corresponding receptors in association with tubulointerstitial lesions in a rat ang II infusion model.

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