The G Protein–Coupled Receptor Kinase 4 Gene Affects Blood Pressure in Young Normotensive Twins
Author(s) -
Hongyan Zhu,
Yuan Lu,
Xianhuo Wang,
Frank A. Treiber,
G HARSHFIELD,
Harold Snieder,
Yuxiang Dong
Publication year - 2006
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1016/j.amjhyper.2005.07.007
Subject(s) - medicine , allele , endocrinology , haplotype , blood pressure , locus (genetics) , reabsorption , receptor , genetics , gene , biology , kidney
G protein-coupled receptor kinase 4 (GRK4) is involved in activity of dopamine receptors in renal proximal tubules and thus mediates sodium reabsorption and blood pressure (BP) regulation. The present study evaluated the impact of the GRK4 gene variants on BP levels in normotensive adolescents and young adults.
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