Genetic Variations in CC Chemokine Receptors and Hypertension | Zendy

M ZHANG | Zendy; Kristin G. Ardlie | Zendy; Sholom Wacholder | Zendy; Richard M. Welch | Zendy; Stephen J. Chanock | Zendy; Thomas O’Brien | Zendy

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Genetic Variations in CC Chemokine Receptors and Hypertension

Author(s) -

M ZHANG,

Kristin G. Ardlie,

Sholom Wacholder,

Richard M. Welch,

Stephen J. Chanock,

Thomas O’Brien

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.06.025

Subject(s) - chemokine receptor , ccr2 , medicine , chemokine receptor ccr5 , c c chemokine receptor type 6 , cc chemokine receptors , immunology , genetics , gene , receptor , chemokine , polymorphism (computer science) , biology , genotype

CC-chemokine receptor 5 (CCR5) is a co-receptor for human immunodeficiency virus type 1 (HIV-1) infection. Homozygosity for a 32-base pair (bp) deletion (Delta32) in the CCR5 gene confers resistance to HIV-1. Previous studies found an increased prevalence of hypertension among CCR5-Delta32 homozygotes and among carriers of a polymorphism (CCR2-64I) found on the gene that codes a closely related chemokine receptor. The present study was carried out to verify these associations.

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