Expression of Glucose Transporter-1 and Aquaporin-4 in the Cerebral Cortex of Stroke-Prone Spontaneously Hypertensive Rats in Relation to the Blood-Brain Barrier Function | Zendy

Hiroaki Ishida | Zendy; Kumiko Takemori | Zendy; Kensaku Dote | Zendy; Hiroyuki Ito | Zendy

Open Access

Expression of Glucose Transporter-1 and Aquaporin-4 in the Cerebral Cortex of Stroke-Prone Spontaneously Hypertensive Rats in Relation to the Blood-Brain Barrier Function

Author(s) -

Hiroaki Ishida,

Kumiko Takemori,

Kensaku Dote,

Hiroyuki Ito

Publication year - 2006

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.06.023

Subject(s) - medicine , aquaporin 4 , blood–brain barrier , stroke (engine) , cerebral cortex , glucose transporter , pathogenesis , astrocyte , aquaporin , neuroscience , transporter , endothelium , endocrinology , central nervous system , biology , physiology , gene , insulin , mechanical engineering , biochemistry , engineering

Cerebral edema is an important initial event in cases of stroke among humans. Although hypertension is a major risk factor for endothelial injury, the precise mechanisms regulating brain microvascular changes are still unknown. To elucidate the pathogenesis of increases in vascular permeability in the cerebral cortex, we investigated the expression of glucose transporter-1 (GLUT-1) in endothelial cells and aquaporin-4 (AQP4) in astrocytes in relation to blood-brain barrier (BBB) function.

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