Triple Vasopeptidase Inhibition Normalizes Blood Pressure in Conscious, Unrestrained, and Spontaneously Hypertensive Rats | Zendy

Philippe Daull | Zendy; Ouhida Benrezzak | Zendy; Dominique Arsenault | Zendy; L.H. Pheng | Zendy; A Blouin | Zendy; Julie Cayer | Zendy; M. Beaudoin | Zendy; Karine Belleville | Zendy; Pierré Sirois | Zendy; F. Nantel | Zendy

Open Access

Triple Vasopeptidase Inhibition Normalizes Blood Pressure in Conscious, Unrestrained, and Spontaneously Hypertensive Rats

Author(s) -

Philippe Daull,

Ouhida Benrezzak,

Dominique Arsenault,

L.H. Pheng,

A Blouin,

Julie Cayer,

M. Beaudoin,

Karine Belleville,

Pierré Sirois,

F. Nantel

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.06.022

Subject(s) - medicine , neprilysin , blood pressure , vasoactive , endocrinology , renin–angiotensin system , bradykinin , hemodynamics , angiotensin converting enzyme , endothelin receptor , angiotensin ii , spontaneously hypertensive rat , ace inhibitor , enzyme , pharmacology , receptor , biochemistry , chemistry

CGS 35601 is a potent triple vasopeptidase inhibitor (VPI) of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP), and endothelin-converting enzyme (ECE). The aim of the study was to determine the effects of this VPI on the hemodynamic profile of conscious, instrumented, unrestrained spontaneously hypertensive rats (SHR), in comparison to selective inhibitors of ACE and ACE + NEP, than +ECE combined. Circulating plasma concentrations of vasoactive mediators and reactive oxygen species were measured.

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