Salt Intake Affects the Relation Between Hypertension and the T-786C Polymorphism in the Endothelial Nitric Oxide Synthase Gene | Zendy

Koichi Miyaki | Zendy; Shugo Tohyama | Zendy; Masayuki Murata | Zendy; H Kikuchi | Zendy; Izumi Takei | Zendy; K. Watanabe | Zendy; Kenji Omae | Zendy

Open Access

Salt Intake Affects the Relation Between Hypertension and the T-786C Polymorphism in the Endothelial Nitric Oxide Synthase Gene

Author(s) -

Koichi Miyaki,

Shugo Tohyama,

Masayuki Murata,

H Kikuchi,

Izumi Takei,

K. Watanabe,

Kenji Omae

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.06.012

Subject(s) - medicine , endothelial nitric oxide synthase , nitric oxide synthase , gene polymorphism , polymorphism (computer science) , gene , nitric oxide , endocrinology , genotype , genetics , biology , enos

Recent genetic studies have shown an association between the T-786C polymorphism in the endothelial NO synthase gene and coronary artery diseases, but any possible association with hypertension has been controversial. Other studies indicate the effect of restricting salt intake differ depending on individual salt-sensitivity, and the mixture of different sensitivity in study subjects may obscure the results. The objective of this study was to investigate the gene-environment interaction between the salt intake and this polymorphism.

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