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The recognition that some 10% to 15% of the hypertensive population may have aldosterone excess has increased the frequency of measurement of the aldosterone-to-renin ratio (ARR) and the use of aldosterone antagonists. Whether this ratio will predict the blood pressure (BP) response to spironolactone is not clear.

Does Aldosterone-to-Renin Ratio Predict the Antihypertensive Effect of the Aldosterone Antagonist Spironolactone?