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Endothelin contributes to the maintenance of vascular tonus in both the systemic circulation and in regional vascular beds. The purpose of the study was to measure the effect of the endothelin A antagonist BQ-123 on renal hemodynamics, tubular function, vasoactive hormones, and blood pressure (BP) in healthy men.

american journal of hypertension

Effect of BQ-123, an Endothelin Antagonist, on Renal Hemodynamics, Tubular Function, Vasoactive Hormones, and Blood Pressure in Healthy Humans: A Dose Response Study