Hypertension Induced by Aortic Coarctation Above the Renal Arteries Is Associated With Immune Cell Infiltration of the Kidneys | Zendy

Bernardo RodríguezIturbe | Zendy; Yasmir Quiroz | Zendy; Choong Hyun Kim | Zendy; N.D. Vaziri | Zendy

Open Access

Hypertension Induced by Aortic Coarctation Above the Renal Arteries Is Associated With Immune Cell Infiltration of the Kidneys

Author(s) -

Bernardo RodríguezIturbe,

Yasmir Quiroz,

Choong Hyun Kim,

N.D. Vaziri

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.05.034

Subject(s) - medicine , infiltration (hvac) , kidney , inflammation , angiotensin ii , immune system , aorta , blood pressure , endocrinology , immunology , physics , thermodynamics

Renal tubulointerstitial infiltration of activated T cells and macrophages is invariably present and plays a role in elevation of arterial pressure in nearly all animal models of hypertension (HTN). The role, if any, of elevated renal arterial pressure in the pathogenesis of this inflammatory process is uncertain. Also unclear is whether the cellular infiltration is caused by the local activation of immune cells in the kidney or a consequence of leukocyte activation in the systemic circulation.

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