Reduction of Pneumonia Risk by an Angiotensin I–Converting Enzyme Inhibitor in Elderly Japanese Inpatients According to Insertion/Deletion Polymorphism of the Angiotensin I–Converting Enzyme Gene | Zendy

Takashi Takahashi | Zendy; S MORIMOTO | Zendy; Kohya Okaishi | Zendy; Tsutomu Kanda | Zendy; Takeshi Nakahashi | Zendy; Masashi Okuro | Zendy; Hiroyuki Murai | Zendy; Yuki Nishimura | Zendy; Kunimitu Iwai | Zendy; Marcelo Hide Matsumoto | Zendy

Open Access

Reduction of Pneumonia Risk by an Angiotensin I–Converting Enzyme Inhibitor in Elderly Japanese Inpatients According to Insertion/Deletion Polymorphism of the Angiotensin I–Converting Enzyme Gene

Author(s) -

Takashi Takahashi,

S MORIMOTO,

Kohya Okaishi,

Tsutomu Kanda,

Takeshi Nakahashi,

Masashi Okuro,

Hiroyuki Murai,

Yuki Nishimura,

Kunimitu Iwai,

Marcelo Hide Matsumoto

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.04.020

Subject(s) - medicine , angiotensin converting enzyme , ace inhibitor , odds ratio , pneumonia , confounding , genotype , univariate analysis , gastroenterology , endocrinology , blood pressure , multivariate analysis , genetics , biology , gene

We have reported that use of angiotensin I-converting enzyme (ACE) inhibitor, which is a class of antihypertensive agent that induces cough, is an independent factor in reducing risk of pneumonia among elderly inpatients. Insertion/deletion (I/D) polymorphism of the ACE gene (ACE) has been associated with the risk of pneumonia in elderly individuals. However, the ability of ACE inhibitors to reduce pneumonia-related morbidity in individuals with the ACE polymorphism is unclear. Therefore we determined the association of ACE inhibitor use and ACE genotypes with reduction of pneumonia risk in the Japanese elderly population.

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